Leading musicians such as Walter Weller, Heinz Wallberg, Miltiades Caridis, Fabio Luisi, Kristjan Järvi and Andrés Orozco-Estrada have been principal conductors of the Tonkunstler. The orchestra has also received significant musical inspiration from its guest conductors. It has enjoyed friendly and often long-standing collaborations with respected conductors such as Michael Schønwandt, Jun Märkl, Jeffrey Tate, Hugh Wolff, Giovanni Antonini, Krzysztof Urbanski, Dmitrij Kitajenko and John Storgårds.
Soloists who have collaborated with the orchestra include Renée Fleming, Joyce DiDonato, Angelika Kirchschlager, Lisa Batiashvili, Sol Gabetta and Michael Schade amongst many others as well as the pianists Rudolf Buchbinder, Fazil Say, Kit Armstrong and Lang Lang. Violin virtuosos Christian Tetzlaff, Augustin Hadelich, Arabella Steinbacher and Julia Fischer, as well as the oboist Albrecht Mayer and harpist Xavier de Maistre have also made appearances with the Tonkunstler.
In 2003 the Tonkunstler were the first Austrian orchestra to establish a department for music education. The «Tonspiele» are now one of Austria’s most extensive programmes of musical education. Plentiful CD recordings reflect the orchestra’s artistic profile. On its newly-founded independent label the Tonkunstler and Yutaka Sado have recently released recordings of works by Richard Strauss, Joseph Haydn and Anton Bruckner.